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For both Alzheimer Disease (AD) and Parkinson disease (PD) the greatest neuronal loss was found in the locus coeruleus (LC). In AD, neuronal loss was most severe and best correlated with the duration of illness in the LC, rather than in nucle us basalis (NB) as traditionally expected. Correlations between neuronal loss in the LC and NB (but not SN) in both PD and AD suggest that the former 2 nuclei may share common pathogenetic susceptibilities. Given the prominent loss of neurons in the LC, d etection and treatment of noradrenergic deficiencies warrant attention in both AD and PD. |
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